交叉呈遞

交叉呈遞（Cross-presentation）是一些抗原呈遞細胞具有能將外源型抗原使用MHC Ⅰ類分子呈遞至CD8+ T細胞（細胞毒性T細胞，CTL）的能力。交叉呈遞可以造成交叉致敏（Cross-priming），激活初始細胞毒性CD8+ T細胞^[1]。交叉呈遞對於免疫系統抵抗不侵染抗原呈遞細胞（APC）或能削弱树突状细胞（DC）的大部分腫瘤和病毒來說至關重要^[2]^[3]。此外，交叉呈遞對於使用蛋白質抗原的疫苗（比如腫瘤疫苗）接種來說也是必要的，因爲交叉呈遞可以誘導細胞免疫^[4]。

參見[编辑]

參考[编辑]

^ Bevan, Michael J. Cross-priming. Nature Immunology (Nature Publishing Group). 2006, 7 (4): 363–365 [2016-10-30]. PMID 16550200. doi:10.1038/ni0406-363. （原始内容存档于2009-04-16）.
^ Heath, WR; Carbone, FR. Cross-presentation in viral immunity and self-tolerance. Nat Rev Immunol. 2001, 1 (2): 126–34. PMID 11905820. doi:10.1038/35100512.
^ Rock, KL. A new foreign policy: MHC class I molecules monitor the outside world. Immunol. Today. 1996, 17 (3): 131–7. PMID 8820271. doi:10.1016/0167-5699(96)80605-0.
^ Melief, CJ. Mini-review: Regulation of cytotoxic T lymphocyte responses by dendritic cells: peaceful coexistence of cross-priming and direct priming?. Eur J Immunol. 2003, 33 (10): 2645–54. PMID 14515248. doi:10.1002/eji.200324341.

[1] Bevan, Michael J. Cross-priming. Nature Immunology (Nature Publishing Group). 2006, 7 (4): 363–365 [2016-10-30]. PMID 16550200. doi:10.1038/ni0406-363. （原始内容存档于2009-04-16）.

[Heath-2] Heath, WR; Carbone, FR. Cross-presentation in viral immunity and self-tolerance. Nat Rev Immunol. 2001, 1 (2): 126–34. PMID 11905820. doi:10.1038/35100512.

[3] Rock, KL. A new foreign policy: MHC class I molecules monitor the outside world. Immunol. Today. 1996, 17 (3): 131–7. PMID 8820271. doi:10.1016/0167-5699(96)80605-0.

[4] Melief, CJ. Mini-review: Regulation of cytotoxic T lymphocyte responses by dendritic cells: peaceful coexistence of cross-priming and direct priming?. Eur J Immunol. 2003, 33 (10): 2645–54. PMID 14515248. doi:10.1002/eji.200324341.

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