普列克底物蛋白

普列克底物蛋白
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2I5C、2I5F、2CSO、1W4M、1XX0、1PLS、1X05、1ZM0
識別號
别名	PLEK；, Pleckstrin, pleckstrin, P47
外部ID	OMIM：173570 MGI：1860485 HomoloGene：2000 GeneCards：PLEK
相關疾病
	乳糜泻
基因位置（人类）
染色体	2號染色體
终止	68,397,453 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	17,002,381 bp
基因本體
分子功能	• protein homodimerization activity; • phosphatidylinositol-3,4-bisphosphate binding; • 血浆蛋白结合; • protein kinase C binding;
細胞組分	• 細胞質; • 细胞质基质; • 膜; • ruffle membrane; • 細胞外區域;
生物學過程	• actin cytoskeleton reorganization; • thrombin-activated receptor signaling pathway; • intracellular signal transduction; • phospholipase C-inhibiting G protein-coupled receptor signaling pathway; • phosphatidylinositol metabolic process; • regulation of cell diameter; • ruffle organization; • platelet degranulation; • positive regulation of integrin activation; • protein kinase C signaling; • vesicle docking involved in exocytosis; • positive regulation of inositol-polyphosphate 5-phosphatase activity; • cell projection organization; • hematopoietic progenitor cell differentiation; • integrin-mediated signaling pathway; • negative regulation of calcium-mediated signaling; • positive regulation of actin filament bundle assembly; • protein secretion by platelet; • negative regulation of G protein-coupled receptor signaling pathway; • platelet aggregation; • cortical actin cytoskeleton organization; • positive regulation of platelet activation; • positive regulation of actin filament depolymerization; • negative regulation of inositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	5341
	56193
	ENSG00000115956
	ENSMUSG00000020120
	P08567
	Q9JHK5
	NM_002664
	NM_019549
	NP_002655
	NP_062422
	維基數據
檢視/編輯人類	檢視/編輯小鼠

普列克底物蛋白（Pleckstrin）是一个发现于血小板的蛋白。其命名中“plec”来源于血小板及白细胞C激酶底物（platelet and leukocyte C kinase substrate），“kstr”来自于氨基酸序列KSTR（赖氨酸-丝氨酸-苏氨酸-精氨酸）。

此名词是PH结构域（pleckstrin 同源结构域，pleckstrin homology domain）和DEP结构域（Dishevelled, Egl-10 and Pleckstrin domain，DEP domain）的词源。

中文暂名：普列克底物蛋白

参考文献

^ 與普列克底物蛋白相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000115956 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020120 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

外部链接

醫學主題詞表（MeSH）：pleckstrin

[1] 與普列克底物蛋白相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000115956 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020120 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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